Paris, France; 22 March: DEINOVE (Euronext Growth Paris: ALDEI), a French biotech company that uses a disruptive approach to develop innovative antibiotics and bio-based active ingredients for cosmetics and nutrition, announces that it has successfully completed the first key milestone of the AGIR program – Antibiotics against Resistant Infectious Germs – which is supported by the Investments for the Future Program. This milestone triggered the payment of €1.5m. AGIR is a platform dedicated to the search for unprecedented antibiotic structures from rare bacterial strains.

The AGIR program aims to explore the antimicrobial potential of rare bacterial strains with the objective of identifying new antibiotic structures and developing innovative treatments to address the health challenge of increasing antimicrobial resistance.

The goal for DEINOVE is to accelerate the screening of antibiotic activities of multiple strains under various conditions in order to quickly detect new antimicrobial structures. The first stage of the AGIR program led to the development of a robotic platform for extracting and screening strains. The high-tech equipment has been consolidated and the experimental protocols validated.

“With our robotic platform, we now have a unique tool to explore the potential of many rare microorganisms, both from our proprietary library, our targeted collection activities, and samples provided by our research partners[1]. First bacterial extracts of interest have been identified and are currently being dereplicated, in order to identify the molecule that is causing the antibiotic activity and verify its innovative character. We want to move fast because antibiotic resistance is progressing rapidly throughout the world and represents a major danger to mankind with projections on deaths amounting to 10 million from 2050 onwards[2],” says Georges GAUDRIAULT, Scientific Director of DEINOVE.

The division Next-generation anti-infectives which is one of DEINOVE’s strategic pillars was initially developed by DEINOBIOTICS, a subsidiary wholly-owned by DEINOVE. A decision was taken to merger DEINOBIOTICS into DEINOVE through a total asset transfer on November 1, 2018, after which DEINOBIOTICS was removed from the Trade and Companies Register.

ABOUT THE AGIR PROGRAM: The AGIR program – Antibiotics Against Resistant Infectious Germs – was selected in 2017 by the Investments for the Future Program and receives from Bpifrance a financial support of €14.6m over 5 years.

The AGIR program aims to explore a wide-ranging biodiversity, mainly rare micro-organisms in order to identify and develop a portfolio of drug candidates.

While the world lacks new antibiotics, research is still predominantly focused on a small number of micro-organisms of interest or on the construction by chemical synthesis of molecules derived from existing drugs.

Conversely, the AGIR program is developing new methods of collection, culture, evaluation of the antibiotic potential of rare bacterial strains, and optimization of the molecules of interest.

The AGIR program is run with the Charles Viollette Institute which brings its expertise in enzymatic engineering and characterization.

An ambitious collaborative project strengthened by targeted strategic partnerships to broaden the scope of research

Capitalizing on its technology that allows it to automate and accelerate the analysis of large quantities of strains, DEINOVE aims to maximize the opportunities to discover new antibiotic structures by expanding its field of research beyond its own bacterial library.

The Company has entered into partnerships with several companies, including bioMérieux and Naicons, with portfolios of diverse strains collected as part of their pharmaceutical activities.